In Vitro to In Vivo Screening Across Model Systems Uncovers a New GABA Receptor Modulator

We employed compound library screening in the zebrafish, Danio rerio, chemical genetics in the worm, Caenorhabditis elegans, electrophysiological analysis in mouse and human brain slices, and preclinical validation in mouse seizure models to identify a novel antiseizure medicine, chlorothymol. This study establishes a new screening approach across preclinical models.